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Microbiology

Confirmation of diseases of public health importance under the IDSP (Integrated Disease surveillance Project) State surveillance net work (Referral Lab)

Funding Agency: Govt. of Maharashtra
Duration: 2010 onwards
Principal Investigator: Deotale V, Maraskolhe D
Ethics Approval:

The Integrated Disease Surveillance Project (IDSP) aims to improve the disease surveillance in the country and support the strengthening of the public health laboratories at different levels to enable confirmation of agents causing outbreaks to enable appropriate local response. The two authorities, namely State surveillance Unit (SSU), Maharashtra and our medical college have decided to cooperate and collaborate with each other in order to provide access, to the selected districts of the state, to a quality assured referral lab for confirmation of disease outbreaks of epidemic prone diseases under the state referral lab network plan using an output based arrangement.

We are providing services as state referral laboratory under IDSP for the following district as per agreed terms in the MoU - Wradha, Chandrapur, Yavatmal, Gadchiroli.

Services provided by our college are – · Microbiological testing for outbreak investigation in the linked district. · Provide support to the Rapid Response Teams of the linked districts (Such as providing transport media etc). · Participate in training / mentoring of lab technicians of attached district laboratories. · Strengthen internal quality control following Standard Operating Procedure. · Report the lab results of outbreak related samples to the DSO and SSO expeditiously maintaining confidentiality.

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Sentinel Surveillance Hospitals Vector Borne Disease

Funding Agency: Govt. of Maharashtra
Duration: 2011 onwards
Principal Investigator: Thamke D, Deotale V, Attal R
Ethics Approval:

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Surveillance of selected zoonotic diseases in Central India

Funding Agency: ICMR
Duration: 2015 onwards
Principal Investigator: Narang R, Deshmukh P, Deotale V, Maraskolhe D, Jain M, Narang U, Raut A, Kalore DR, Kurkure NV
Ethics Approval:

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Multi-centric cohort study of recurrence of tuberculosis among newly diagnosed sputum positive pulmonary tuberculosis patients treated under RNTCP: Version 6.0: 18 Jan 2014

Funding Agency: Central TB Division
Principal Investigator: Dr P Narang, Dr Rahul Narang, DTO Wardha and CTO Nagpur
Ethics Approval: Institutional Ethics Committee, (MGIMS/IEC/ 34/2010 dated 03.08.2010)

In the RNTCP, newly diagnosed smear – positive tuberculosis patients are treated with a 6-month thrice-weekly regimen, consisting of an initial intensive phase for two months followed by a continuation phases for four months, given under direct observation. The country reports around 87% ‘cure’ among smear-positive patients treated with this regimen. A TB recurrence rate of 10-12% has been reported from localized studies. There is little information on the proportion and predictors of patients who develop recurrent TB among those patients who had a successful outcome at the end of treatment and on proportion of recurrence TB due to re-infection or to endogenous reactivation. This knowledge would have a bearing on the efficacy of the regimen. This study is aimed (1) to estimate the recurrence of TB among newly diagnosed sputum positive pulmonary TB patients who have been successfully treated under RNTCP and (2) to distinguish between relapse and re-infection among those who have recurrence of TB and (3) identify risk factors for unfavourable treatment outcomes (treatment failed, lost to treatment follow-up and died) and recurrence.

This is a prospective, multi-centric cohort study being conducted at six centers -MGIMS is one such center. The other centers are National Institute for Research in Tuberculosis (NIRT), Chennai, National Tuberculosis Institute (NTI), Bangalore, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, Regional Medical Research Centre for Tribals (RMRCT), Jabalpur, Thiruvananthapuram Medical College, Thiruvananthapuram (TMCT). New smear positive PTB patients treated under RNTCP are enrolled. They are being followed up till they complete treatment, and those with successful treatment outcome will be followed up for a period of 12 months after completing treatment. These patients are subjected to the following procedures: Structured interview, sputum examination for TB smear, culture, DST and genotyping and blood test for diabetes mellitus and HIV infection.

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Multi centric hospital based surveillance of acute encephalitis syndrome of viral etiology among children in selected districts of Maharashtra and Andhra Pradesh

Funding agency: ICMR
Principal Investiagtor: Dr. Rahul Narang, Dr Manish Jain, Dr Vijayshri Deotale, Dr Nitian Gangane, Dr Ruchita Attal and Investigators from JNMC Sawangi (Meghe) & VNGMC Yavatmal
Ethics Approval: Obtained from Institutional Ethics Committee, (MGIMS/IEC/APRIL/36/2011 dated 20/04/2011)

Surveillance is an integral part for any disease control programme, especially for acute encephalitis syndromes (AES) like Japanese encephalitis (JE) and Chandipura viral encephalitis, which have epidemic potential with high case fatality. An intensified surveillance for JE was felt necessary and for the first time in India, a national level “Acute Encephalitis Syndrome (with Special Reference to Japanese Encephalitis) surveillance guidelines” were developed in November 2006 by Directorate of National Vector Borne Diseases Control Programme. Chandipura virus (CHPV) is a vesiculovirus from the Rhabdoviridae family. Chandipura viral encephalitis is now considered as one of the important cause of AES in central India. By providing laboratory facility in the affected area through collaborations with local institutes, cold chain would be maintained and thus it will maintain the quality of clinical specimen till laboratory testing along with quick reporting of results. This will also help physicians in guiding case management.

MGIMS, along with GMC Nagpur and Kakatiya Medical College (KMC), Warangal, Telangana is working with the National Institute of Virology (NIV) Pune. Viral diagnostic testing for JE and Chandipura virus would be provided free of cost by the site laboratory established in Microbiology Department of MGIMS, as well as two other medical colleges. The project activities are being undertaken by surveillance and investigations of AES cases with the help of hospital pediatricians and health services officials/staff in the area. Clinical specimens from AES cases are being accepted by the site laboratories for provision of viral diagnostic testing for JE IgM and Chandipura virus RT PCR. Since there is one more site laboratory in Vidharba, clinical samples from Nagpur, Bhandara, Gondia and Gadchiroli district are sent to GMC Nagpur and clinical samples from Wardha, Chandrapur, Yavatmal and Amravati to MGIMS.

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